Poster Presentation 13th Australian Peptide Conference 2019

Peptidomimetics targeting the SOCS-SH2 domain  (#223)

Hao Chen 1 2 , Nghi Nguyen 1 2 , Christoph Grohmann 1 2 , Jeff Babon 1 2 , Brad Sleebs 1 2 , Sandra Nicholson 1 2
  1. Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia
  2. Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
Publish consent withheld
  1. Delconte, R.B., et al., CIS is a potent checkpoint in NK cell-mediated tumor immunity. Nat Immunol, 2016. 17(7): p. 816-24.
  2. Palmer, D.C., et al., Cish actively silences TCR signaling in CD8+ T cells to maintain tumor tolerance. J Exp Med, 2015. 212(12): p. 2095-113.
  3. Chikuma, S., et al., Suppressors of cytokine signaling: Potential immune checkpoint molecules for cancer immunotherapy. Cancer Sci, 2017. 108(4): p. 574-580.